Taysha Gene Therapies Receives Rare Pediatric Disease Designation and Orphan Drug Designation for TSHA-102 as a Treatment for Rett Syndrome

Program leverages novel miRARE platform technology used to control transgene expression on a cellular basis

TSHA-102 anticipated to submit Investigational New Drug application in 2021

Taysha Gene Therapies Inc. (Nasdaq: TSHA), a patient-centric gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system in both rare and large patient populations, today announced that it has received rare pediatric disease designation and orphan drug designation from the U.S. Food and Drug Administration (FDA) for TSHA-102, an AAV9-based gene therapy in development for the treatment of Rett syndrome. Taysha anticipates that it will submit an Investigational New Drug (IND) application for TSHA-102 to the FDA in 2021.

Rett syndrome is one of the most common genetic causes of severe intellectual disability worldwide, with a prevalence of over 25,000 cases in the U.S. and European Union (EU). It is an X-linked disease that primarily occurs in females, but it can be seen very rarely in males. It is usually recognized in children between six to 18 months of age as they begin to miss developmental milestones or lose abilities they had developed. Individuals with Rett syndrome also show symptoms that include loss of speech, loss of purposeful use of hands, loss of mobility, seizures, cardiac impairments, breathing issues and sleep disturbances.

“Patients with Rett syndrome are currently managed with symptomatic treatments as there are no therapies approved to treat the underlying cause of disease,” said Berge Minassian, M.D., Chief Medical Advisor of Taysha and Chief of Pediatric Neurology at the University of Texas Southwestern Medical Center (UT Southwestern). Dr. Minassian is credited with describing the CNS isoform of the MECP2 gene which is responsible for neuronal and synaptic function throughout the brain. “Gene therapy offers a potentially curative option for patients suffering with Rett syndrome.”

Rett syndrome is caused by mutations in the MECP2 gene. TSHA-102 is designed to deliver a healthy version of the MECP2 gene as well as the miRNA-Responsive Auto-Regulatory Element, miRARE, platform technology to control the level of MECP2 expression. “TSHA-102 represents an important step forward in the field of gene therapy, where we are leveraging a novel regulatory platform called miRARE to prevent the overexpression of MECP2,” said Steven Gray, Ph.D., Chief Scientific Advisor of Taysha and Associate Professor in the Department of Pediatrics at UT Southwestern. “In collaboration with Sarah Sinnett, Ph.D. to develop miRARE, our goal was to design a regulated construct that allowed us to control MECP2 expression to potentially avoid adverse events that are typically seen with unregulated gene therapies.”

The FDA defines a rare pediatric disease as a serious or life-threatening disease in which the disease manifestations primarily affect individuals aged from birth to 18 years. Pediatric diseases recognized as “rare” affect under 200,000 people in the U.S. The Rare Pediatric Disease Priority Review Voucher Program is intended to address the challenges that drug companies face when developing treatments for these unique patient populations. Under this program, companies are

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Dentist Fortitude Valley, Precision Dental, Offers General and Cosmetic Dentistry Solutions in a Caring and Friendly Environment in QLD – Press Release

Dentist Fortitude Valley, Precision Dental, Offers General and Cosmetic Dentistry Solutions in a Caring and Friendly Environment in QLD

Fortitude Valley, QLD – Not every dentist is the same. There are those that will only be concerned about providing treatment while there are others that will go above and beyond in ensuring that patients are feeling comfortable. Precision Dental is a modern dental practice that is based at the heart of Brisbane servicing Fortitude Valley and is committed to high-quality dental care. The practice provides both general and cosmetic dental treatment for the whole family.

“Our ultra-modern practice is conveniently located in HQ Towers which offer free onsite parking for the duration of treatment. Emergency appointments are available throughout the day and Saturday appointments can be arranged. We are equipped with the latest generation of equipment and pride ourselves in providing thorough dental treatment that is tailored to individual needs and goals.” Said Dr Billy Choi, the spokesperson for the clinic, regarding their unrivalled services.

The dental practice was founded on three key principles including honesty, patient comfort, and quality. Every member of the staff will ensure that patients are comfortable right from the moment they walk in their office. The clinic uses the latest generation of quiet equipment to ensure that dental visits are enjoyable. Some of the tools that can be found in the treatment room to make patients relax include:


Parents can rest easy knowing that the clinic offers children’s dental emergency treatments. Children have high energy and are always going to be susceptible to dental emergencies. The dentists have knowledge in dealing with such unexpected events and will ensure that children are not experiencing discomfort a minute longer. The practice applies advanced skills in dentistry and state-of-the-art equipment to overcome dental emergencies.

The clinic also aims at being the leading cosmetic dentistry treatment provider in Fortitude Valley, one smile at a time. The treatment options are tailored to meet the individual needs of the patient. A good dentist Fortitude Valley is one that will start by assessing the individual needs of the patient before coming up with a course of action and this is exactly what you get when you reach out to Precision Dental. Getting a smile makeover will help in maintaining a youthful appearance and also boosts the self-confidence of a person. Patients can enjoy all of these benefits by booking a dental appointment with Precision Dental at their own convenient time.

The clinic also believes in providing education to patients because good dental care requires a holistic approach. The clinic believes that a dentist should be a partner when it comes to the wellbeing of the teeth, gums, and mouth. Precision Dental provides patients with both basic and advanced information so that they’re establishing a consistent and reliable oral care routine. It is also easy for patients to book an appointment when they visit their website.

Precision Dental is located at S13, HQ South Tower, 520 Wickham St, Fortitude Valley, QLD 4006. For enquiries regarding the top-rated dentist Fortitude Valley and the services offered, contact their team by calling (07) 3852 1160

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Med students on how COVID pushed them into action, highlighted health care inequities

It was on a Saturday in mid-March when Abby Schiff, then a third-year medical student at Harvard working through surgery clinical rotations, found out she wouldn’t be going back to the hospital.



a group of people on a sidewalk: Medical student Francis Wright (top left) during a mask drive early on in the pandemic with his classmates (clockwise) India Perez-Urbano, Kara Lau, Lane Epps, Ninad Bhat, Laeesha Cornejo and Hunter Jackson, the last of whom came up with the idea.


© Courtesy Francis Wright
Medical student Francis Wright (top left) during a mask drive early on in the pandemic with his classmates (clockwise) India Perez-Urbano, Kara Lau, Lane Epps, Ninad Bhat, Laeesha Cornejo and Hunter Jackson, the last of whom came up with the idea.

She had worked the day before, but with the coronavirus threat growing quickly, Schiff, like thousands of other medical students across the country, was sidelined when the Association of American Medical Colleges issued a temporary suspension of clinical rotations in hopes of protecting students and patients, and conserving personal protective equipment (PPE).

She didn’t sit around waiting, though. As nurses came out of retirement and medical school professors pressed pause on teaching to answer the call to action on the front lines, Schiff also got to work. Within hours, she and a group of other students started building a crash course on COVID-19 for medical professionals.

“At the time, a lot of Harvard medical students were talking about what was going on, and [it] felt like we suddenly had a lot of time on our hands,” Schiff told ABC News. “There was this crisis going on. How can we best contribute?”



a woman standing in front of a book shelf: Abby Schiff, a fourth-year medical student at Harvard Medical School, helped to create the school's COVID-19 curriculum and still keeps it updated on a regular basis.


© ABC News
Abby Schiff, a fourth-year medical student at Harvard Medical School, helped to create the school’s COVID-19 curriculum and still keeps it updated on a regular basis.

In less than a week, 70 of Schiff’s colleagues, including students and faculty, had put together a comprehensive, open-source COVID-19 curriculum.

“So we had about 80 pages of content — all referenced, all freely available — including things like thought questions, quiz questions… helpful information about how to put on masks and PPE, run ventilators,” she said. “And then also an explainer about basic epidemiological terms, about sort of the basics of virology and immunology and the clinical manifestations that were known at the time.”

Seven months later, the curriculum is still being updated with the latest science on a regular basis. Today, it includes modules on mental health, global health and communication, all meant to “dispel misinformation and myths,” said Schiff.



graphical user interface, application: Fourth-year Harvard medical student Abby Schiff (second from top left) attends a video meeting with her fellow students to discuss updates to their school's open-source COVID-19 curriculum.


© Courtesy Abby Schiff
Fourth-year Harvard medical student Abby Schiff (second from top left) attends a video meeting with her fellow students to discuss updates to their school’s open-source COVID-19 curriculum.

As co-chair for outreach, she said her role is to reach out to students and groups that are using the curriculum to get an idea of their needs and how they can best be met, as well as recruiting students to contribute. The curriculum has already been implemented in 32 medical schools across the country as either an elective or mandatory course, and it has been translated into 27 languages and used in at least 110 countries, Schiff said.

“It’s had a really wide reach, including in areas where

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Summa Equity Acquires Sengenics to Advance Precision Medicine Through Proteomics

Summa Equity, the purpose-driven private equity firm that invests to solve global challenges, has acquired a majority stake in Sengenics, a functional proteomics company with a proprietary technology called KREX that enables researchers to vastly improve the understanding of the human proteome and immune system. Proteomics, i.e. the large-scale study of proteins, is one of the most important areas for gaining insights into human biology and disease, as protein expressions, structures and functions are critical in reflecting states of health.

Sengenics was first founded in 2008 and went on to commercialise the KREX technology that was originally developed from a joint collaboration between the University of Cambridge and the University of Oxford. The company’s patented KREX technology enables researchers to address both the function and folding structure of proteins using one technology that allows for large numbers of proteins to be studied simultaneously, with high sensitivity and specificity. The combination of these capabilities makes KREX unique. The technology is relevant for a broad range of applications in research and throughout the value chain for drugs, vaccines and diagnostics. Sengenics is currently mainly focused on autoantibody detection for applications in autoimmune diseases, oncology and infectious diseases, including COVID-19. The company recently launched a unique high-throughput, multi-antigen, multi-domain and fully quantitative COVID-19 test, leveraging the KREX technology.

Sengenics has grown rapidly in recent years and established customer relationships with top global pharmaceutical companies, and leading research and academic institutions around the world. The company currently has commercial partnerships with 9 out of the top 10 pharmaceutical companies to co-develop complementary and companion diagnostic tests for autoimmune and cancer immunotherapy drugs. Sengenics is based in Europe and South-East Asia.

“Sengenics’ proprietary technology unlocks tremendous potential for researchers around the world to further their understanding of biology and disease,” says Tommi Unkuri, Partner at Summa Equity. “We are proud to partner with the company and support its journey, as it looks to expand its position in the market and grow its business. We look forward to supporting the Sengenics team in our shared ambition to invest to drive product development, global expansion and accelerated adoption.”

Summa Equity invests in companies that address global challenges, while managing environmental, social, and governance (ESG) factors, with the aim of increasing returns and reducing risk. It was the first company to align its investments with the UN Sustainable Development Goals. The investment in Sengenics is aligned with the firm’s Changing Demographics theme and supports the SDG Target #3: “Ensure healthy lives and promote well-being for all at all ages”, by enabling improved diagnosis, treatment and patient outcomes across a number of disease areas.

“We are excited to welcome Summa Equity as a major strategic investor and shareholder in Sengenics. Their extensive capabilities and alignment with our vision of changing the future of medicine through immune-proteomics is a very strong strategic fit. Summa also has a great deal of relevant knowledge and experience to be a value-added owner for us given its ownership of Olink Proteomics. This

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Porter dentist offers free oral cancer screenings for firefighters

As a thank you to local first responders, Porter Family Dentistry is offering free oral cancer screenings to firefighters in Montgomery County for the next several weeks.

The screenings will be held on Fridays when the office is usually closed so that firefighters don’t have to wait.

In 2016, the National Institute for Occupational Safety and Health published a multi-year study of cancer rates in firefighters, and the findings showed that firefighters had a higher number of cancer diagnoses and cancer-related deaths than the general U.S. population. Among the cancers found in the sample of nearly 30,000 firefighters, those most often found were digestive, oral, respiratory, and urinary cancers.

In recent months, firefighters across the country have been traveling to areas, like California, that their help is needed. Dr. Mustafa Yamani of Porter Family Dentistry went to school in California and has fond memories of the nature and beauty of the state.

“It’s such a beautiful place, it’s really sad reading all of the stuff in the news that’s going on there,” Yamani said. “From all around the country they (the firefighters) come together and they provide this service. It’s just amazing what they’re doing and I really appreciate that. I just want to do something for them.”


The generous act of the firefighters inspired him to give back, and since oral cancer screenings are a service his office already offers he decided to give them to firefighters for free.

While this is the first year that the dental office has offered free screenings, Yamani and his wife Sabrina, who is the office manager, plan on making it an annual thing. The trials of 2020 also helped them decide to give back.

“Things seem to be going from bad to worse, to even worse, and it just doesn’t seem to be stopping for our first responders,” Sabrina said. “They’re just being hit with things one after the other.”

Sabrina started by reaching out to fire departments in the east past of Montgomery County to let them know about the opportunity and the response was immediate and positive. Already, the dental office has screenings set up with local firefighters.

Because firefighters are at a higher risk of developing cancer, many departments take an aggressive approach to screenings and check-ups. Early detection is vital. Such is the approach of the East Montgomery County Fire Department where firefighters undergo a National Fire Protection Agency physicals annually.

“It’s huge to us,” Eran Denzler, captain and PIO with the department, said of being able to get the oral screenings for free. “It’s a great show of appreciation for what we do and the risks that we take. Every day we go and put our lives on the line for the community, and for them to give back and worry about our safety is something we’re not used to but it’s much appreciated.”

The department averages around one to two structure fires a week,

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Beyond Celiac Chosen by 9 Meters Biopharma as Exclusive Patient Organization to Recruit for First-Ever Phase 3 Clinical Trial

Premier Patient Recruiter for Celiac Disease Research, Beyond Celiac Taps Extensive Network to Advance Study

Go Beyond Celiac, an online patient database launched in 2017, allows its thousands of users to participate in research by sharing their celiac disease stories and experiences and learn how to become involved in research studies such as the Phase 3
Go Beyond Celiac, an online patient database launched in 2017, allows its thousands of users to participate in research by sharing their celiac disease stories and experiences and learn how to become involved in research studies such as the Phase 3
Go Beyond Celiac, an online patient database launched in 2017, allows its thousands of users to participate in research by sharing their celiac disease stories and experiences and learn how to become involved in research studies such as the Phase 3

Philadelphia, PA, Oct. 14, 2020 (GLOBE NEWSWIRE) — Beyond Celiac, the leading catalyst for a celiac disease cure in the United States, today announced it has been chosen by 9 Meters Biopharma, Inc. (Nasdaq: NMTR) as the exclusive patient organization to recruit for the first-ever Phase 3-stage clinical trial therapeutic for treatment of celiac disease. Beyond Celiac will use its unrivaled connection to the celiac disease community and its powerful online patient database to recruit participants for the study of larazotide acetate, which aims to address leaky gut in celiac disease.

“We really listen to our community’s wants and needs. Because of our extensive connection to the people and commitment to connecting researchers with our community, Beyond Celiac has become the partner of choice for leading biotechnology and pharmaceutical companies such as 9 Meters,” said Beyond Celiac CEO Alice Bast. “This is the furthest a celiac disease clinical trial has gone, and it’s an exciting opportunity for our organization to play a vital role in fulfilling its promise.”

9 Meters Biopharma is evaluating larazotide acetate for celiac disease patients who continue to experience gastrointestinal symptoms while following a gluten-free diet. Designed to tighten junctions between intestinal cells, larazotide acetate would act like shoelaces to help restore leaky junctions to a normal state and would be used in addition to the gluten-free diet. It is being tested at more than 100 clinical sites, with a goal of 525 study participants. Results are expected by the end of 2021.

By partnering with Beyond Celiac for recruitment, 9 Meters Biopharma now has access to the power of Go Beyond Celiac, a secure online patient database with thousands of users who share their celiac disease stories and experiences with researchers and seek to become involved in studies.

“Our conservative estimate is that our celiac disease program is at least two years ahead of everyone else’s,” said John Temperato, president and CEO of 9 Meters Biopharma. “Beyond Celiac is going to help us across the finish line in developing the effective treatments that celiac patients deserve.”

Celiac disease is a serious genetic autoimmune disorder that affects an estimated 1 in 133 Americans, more than half of whom are still undiagnosed. The disease causes damage to the small intestine, resulting in debilitating symptoms, and if left untreated, can lead to serious long-term health problems including infertility and some types of cancer.

 

About Beyond Celiac

Founded in 2003,

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Health systems, govt responses linked to virus tolls

BERLIN (AP) — Scientists say a comparison of 21 developed countries during the start of the coronavirus pandemic shows that those with early lockdowns and well-prepared national health systems avoided large numbers of additional deaths due to the outbreak.

In a study published Wednesday by the journal Nature Medicine, researchers used the number of weekly deaths in 19 European countries, New Zealand and Australia over the past decade to estimate how many people would have died from mid-February to May 2020 had the pandemic not happened.

The authors, led by Majid Ezzati of Imperial College London, then compared the predicted number of deaths to the actual reported figure during that period to determine how many likely occurred due to the pandemic. Such models of ‘excess mortality’ are commonly used by public health officials to better understand disease outbreaks and the effectiveness of counter-measures.

The study found there were about 206,000 excess deaths across the 21 countries during the period, a figure that conforms to independent estimates. In Spain, the number of deaths was 38% higher than would have been expected without the pandemic, while in England and Wales it was 37% higher.

Italy, Scotland and Belgium also had significant excess deaths, while in some countries there was no marked change or even — as in the case of Bulgaria — a decrease.


While the authors note that there are differences in the compositions of populations, such as age and the prevalence of pre-existing conditions that contribute to mortality rates, government efforts to suppress transmission of the virus and the ability of national health systems to cope with the pandemic also played a role.

Amitava Banerjee, a professor of clinical data science at University College London who wasn’t involved in the study, said it was well designed and had used standardized methods.

He noted that the comparison between death rates in the United Kingdom and New Zealand, where the age of the population and the rates of pre-existing conditions such as obesity are similar, supports the argument that other factors contributed to the differing mortality figures.

“Even if vaccines and better treatments for severe (COVID-19) infection are developed, the way to minimise excess deaths is to reduce the infection rate through population level measures,” said Banerjee.

These include lockdowns, protecting high risk groups,and establishing effective “test, trace and isolate” systems, he said.

___

Follow AP’s pandemic coverage at http://apnews.com/VirusOutbreak and https://apnews.com/UnderstandingtheOutbreak

Source Article

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Do Musical Instruments Spread the Coronavirus?

As with pretty much every other activity right now, having the quintet gather outdoors is a great idea. If any neighbors complain, explain that the backyard practices are part of a global effort to keep them from dying. If anyone happens to be infected, any virus that emanates in the heat of performance will likely fade into the sky and disperse like the music itself. Indoors, as any parent of a child who’s learning an instrument knows, everything is trapped and can echo around the room indefinitely.

Some instruments do seem to pose more risk than others. Obviously, string instruments can be played without even opening your mouth, but it sounds like your daughter’s quintet is too far along to take kindly to a suggestion that they all learn new instruments. Because the virus is sent into the air by talking, coughing, and singing—any forcible exhalation of air through the pharynx—playing a woodwind or brass instrument would logically pose a risk. These instruments are effectively designed to amplify what’s coming out of our mouths and to carry the sound. A 2011 study of vuvuzelas (the long, straight plastic horns that people blow at soccer games) found that their capacity for spreading infections could be tremendous. Compared with shouting, blowing through the horn sent several hundred times more particles into the air.

Thankfully for everyone, kids don’t train for vuvuzela quintets. Woodwind and brass instruments send air through a maze of twists and turns, and buttons create turbulent airflow patterns that don’t simply shoot everything out in a piercing plume. Breathing into a convoluted contraption such as a saxophone or a tuba, then, actually serves as a sort of filter that collects the larger droplets you might be spewing out. This is familiar to anyone who has emptied a spit valve and seen what pours out.

The real question is the potential danger of smaller, aerosolized particles that can blast out of an instrument and linger in the air. In May, the Vienna Philharmonic reported that it had conducted a study of the aerosols from various instruments. Researchers hooked tubes up to musicians’ noses, and as they played, they inhaled an aerosolized salt solution that could be visualized when it was exhaled. The researchers mapped the clouds of air around musicians while they were playing and reported that none of the instruments sent respiratory droplets beyond the commonly recommended radius of six feet. In most cases, no significant amount of the aerosolized salt particles were detectable coming out the end of the wind and brass instruments. Flutes were the worst offender, passing a “large amount” of aerosol in a cloud covering two and a half feet.

In July, another study in Germany offered findings and hope similar to those from Vienna. But neither study measured actual coronavirus particles, and the overall evidence is still thin. Doctors at the University of Iowa have expressed concern about the rigor of both findings, given

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First Databank Selected as Drug Database Provider for CliniComp, Intl.’s Full-Service EHR Pharmacy Solution

Healthcare industry’s most trusted drug database to drive streamlined inpatient pharmacy workflows for hospitals using CliniComp’s EHR

First Databank, Inc. (FDB), the leading provider of drug and medical device knowledge that helps healthcare professionals make precise decisions, has been selected to supply the drug database for a new and expanded EHR pharmacy module to be offered by CliniComp, Intl., a global provider of hospital-wide clinical documentation systems and electronic health record (EHR) solutions.

CliniComp will integrate the FDB MedKnowledge® database into its EHR to drive a single, full-service pharmacy and medication management system designed to simplify all inpatient pharmacy workflows, including computerized physician order enter (CPOE), medication dispensing and administration.

“Hospitals today need a more robust integrated pharmacy workflow management system within the EHR to make ordering, conflict checking, documenting and dispensing medications easier and more accurate,” said Nancy Pratt, RN, MSN, Senior Vice President Clinical Product Design of CliniComp, Intl. “FDB MedKnowledge will support CliniComp to deliver a more intuitive, easy-to-use solution across all medication workflows, while facilitating meaningful clinical decision support [CDS] alerts, seamless interoperability and smarter data analytics.”

Pratt explained: “We also chose MedKnowledge because the database features excellent organization and structure. This will enable CliniComp to furnish clinicians with access to the right medication information appropriate for their contexts, as well as detailed drug product classifications for more precise selection of drugs.”

Bob Katter, President of FDB, said the alliance will streamline pharmacy workflows to make ordering and dispensing medications more efficient for clinicians. “We will provide CliniComp’s users with meaningful, targeted and actionable medication guidance to support their clinical decision-making,” Katter said. “This will help further improve patient care and safety.”

The new CliniComp pharmacy system powered by FDB MedKnowledge will:

  • Save clinicians time with faster order processing via intelligent dispensing. The system will automate package choice and medication ordering based on criteria such as patient-specific parameters and medication inventory.

  • Save hospitals implementation time via the use of prebuilt medication concepts offered within MedKnowledge. The new full function pharmacy system will provide a foundation from which hospitals can more quickly tailor a solution to meet specific needs.

  • Save hospitals time and resources in updating medication information while ensuring the latest drug data is readily available to clinicians. MedKnowledge will facilitate automated medication updates with minimal post-load maintenance, so there is no downtime.

In addition to FDB MedKnowledge, CliniComp plans to implement the FDB Interoperability Module™ to enhance medication reconciliation and interoperability with external hospital systems, such as automated dispensing cabinets.

About First Databank (FDB)

First Databank (FDB) is the leading provider of drug and medical device knowledge that helps healthcare professionals make precise decisions. We empower our information system developer partners to deliver valuable, useful, and differentiated solutions used by millions of clinicians, business associates, and patients every day. For more than four decades, our medical knowledge has helped improve patient safety, operational efficiency, and healthcare outcomes. For a complete look at our solutions and services, please visit www.fdbhealth.com and follow us on

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Coronavirus UK: Man who couldn’t see a dentist pulls out own teeth

A labourer who lost his income during lockdown pulled out two of his own teeth with pliers and downed eight cans of Stella Artois to numb the pain because he couldn’t get a dental appointment due to the coronavirus crisis.

Chris Savage, 42, resorted to yanking two of his own teeth out in his bedroom because he couldn’t register with a dentist or book an emergency appointment, calling last Thursday’s procedure ‘the most horrible thing I’ve ever done’.

He said he had been in ‘agony’ for days, and revealed that just touching the tooth with his rusty pair of pliers set off waves of ‘agonising pain’.

The labourer, from Southsea in Portsmouth, Hampshire, admitted to getting ‘very drunk’ beforehand by downing eight cans of Stella Artois to mask the pain before he pulled out the first tooth. He then waited a day before pulling out the second tooth.

His case has now been raised with the NHS by a health watchdog who said Mr Savage has been ‘severely let down’ by services in the city.

He said: ‘I ended up having to get very drunk the first time. Nobody wants to take part of their own face away with a set of pliers and no real painkillers.

‘I put the pliers on my tooth and the second I did that it hurt. So I took them away, waited five minutes, built up again and then thought I’ve just got to do it.

Chris Savage, 42, resorted to yanking two of his own teeth out in his bedroom because he couldn't register with a dentist or book an emergency appointment

Chris Savage, 42, resorted to yanking two of his own teeth out in his bedroom because he couldn’t register with a dentist or book an emergency appointment

The labourer said he had been in 'agony' for days, and revealed that just touching the tooth with his rusty pair of pliers set off waves of 'agonising pain'

The labourer said he had been in ‘agony’ for days, and revealed that just touching the tooth with his rusty pair of pliers set off waves of ‘agonising pain’

‘It was a proper yank, a grip and pull — there’s no mucking about once you get to the point it’s started coming out.’

Mr Savage added that though there wasn’t much blood there was ‘enough to be scary’, and that it was ‘worth the risk of infection’.

The father-of-three didn’t register with an NHS dentist when he moved to Portsmouth from Alton three years ago. He lost his two front teeth in a bicycle crash last year, and when he began to experience pain recently he called around 20 dental practices, none of whom were taking on new patients.

He then phoned 111, who directed him to a practice that had volunteered to do triage appointments during the pandemic to help the NHS, but was referred back to 111 when he contacted them.

‘It was like a massive game of pass the parcel’, he said.

Mr Savage signed up to receive Universal Credit during lockdown, leaving him with £50 a week for food and bills, meaning he was reluctant to spend the £100 per tooth it would have cost him to have them removed privately.

He said: ‘I could’ve waited a week — borrowed money, and had it done in hygienic

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